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Filtered Search Results
Apexbio Technology LLC HLCL-61 1158279-20-9 100mg
HLCL-61 (CAS 1158279-20-9) is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5) an enzyme implicated in the epigenetic regulation of gene expression through symmetric dimethylation of arginine residues on histones and other proteins HLCL-61 shows specificity for PRMT5 exhibiting no inhibitory activity against PRMT1 PRMT4 or other type II PRMT family members In cellular studies HLCL-61 suppresses symmetric dimethylation of histones H3 and H4 leading to reduced viability and enhanced differentiation of acute myeloid leukemia (AML) cell lines and primary blasts HLCL-61 is currently utilized in preclinical research to investigate PRMT5-mediated epigenetic mechanisms in cancer
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Medchemexpress LLC PK11007 | 874146-69-7 | 98.7% | 100 MG
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PK11007 is a mild thiol alkylator exhibiting anticancer activity. It stabilizes p53 by selectively alkylating two surface-exposed cysteines without altering its DNA binding activity. This compound induces mutant p53 cancer cell death by elevating reactive oxygen species (ROS) levels. It is intended for research use only.
- Causes viability reduction in mutant p53 cell lines.
- Up-regulates protein levels of p53 target genes.
- Increases p53 activity.
- Increases reactive oxygen species (ROS) levels.
- Inhibits cell proliferation and induces apoptosis.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000744732 SULFOXFLUOR 250MG
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Apexbio Technology LLC Rofecoxib 162011-90-7 250mg
Rofecoxib (CAS 162011-90-7) is a selective inhibitor of cyclooxygenase-2 (COX-2) designed to provide anti-inflammatory effects with improved gastrointestinal tolerance compared to non-selective NSAIDs It demonstrates potent inhibition of COX-2 in cell-based assays with IC50 values ranging from 18 to 46 nM In osteosarcoma cells Rofecoxib suppresses prostaglandin E2 (PGE2) synthesis (IC50 26 nM) and inhibits recombinant human COX-2 in stably transfected CHO cells (IC50 18 nM) In biochemical assays using purified human COX-2 the IC50 is 0 34 M In vivo Rofecoxib reduces carrageenan-induced edema and hyperalgesia in rats (ID50 1 1 5 mg/kg) It is widely used in studies investigating COX-2-mediated inflammatory pathways and analgesia
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Medchemexpress LLC 5-Cholanic acid 50mg
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5 -Cholanic acid is a hydrophobic modifier used to modify polymer carriers 5 -Cholanic acid can improve the acid stability cell penetration efficiency and drug sustained release ability of nanocarriers and optimize the oral effectiveness of delivered molecules 5 -Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells) 5 -Cholanic acid can be used in the development of drug delivery systems[1][2]
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Medchemexpress LLC AP1867-2-carboxymeth 250mg | 2230613-03-1 | 250 MG
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AP1867-2-(carboxymethoxy) is a synthetic FKBP12(F36V)-directed ligand moiety used as the FKBP12-binding component in dTAG and PROTAC constructs. Supplied as a high-purity solid for research applications, it serves as a building block for targeted protein degradation synthesis and assay development.
- High purity solid (99.88%).
- Molecular weight 693.78 g/mol.
- Molecular formula C38H47NO11.
- Suitable for chemical synthesis of dTAG or PROTAC molecules.
- Available in multiple pack sizes, including 250 mg.
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Medchemexpress LLC Thiabendazole (Standard) | 148-79-8 | 99.9% | 250 MG
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Thiabendazole (Standard) is the analytical standard of Thiabendazole. It is intended for research and analytical applications. Thiabendazole inhibits worm-specific fumarate reductase and has anthelmintic properties. It is for research use only and not sold to patients.
- Serves as a reference standard for assays
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
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Medchemexpress LLC Lercanidipine (hydrochloride) | 132866-11-6 | 99.93% | 250 MG
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Lercanidipine hydrochloride is a third-generation, lipophilic, brain-penetrant, vascular-selective, and orally active dihydropyridine-calcium channel blocker with a pIC50 of 7.74. It exhibits long-lasting antihypertensive action and offers reno- and neuro-protective effects, and can be used in cardiovascular and neurological research.
- Functions as a dihydropyridine-calcium channel blocker
- Demonstrates long-lasting antihypertensive action
- Provides reno- and neuro-protective effects
- Exhibits anti-oxidant properties
- Possesses anti-inflammatory properties
- Shows anti-apoptotic properties
- Suitable for cardiovascular and neurological research
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Medchemexpress LLC E3 ligase ligand 64 | 2760850-50-6 | C12H10BrFN4O2 | 250 MG
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E3 ligase Ligand 64 is a ligand for E3 ligase and is used for the synthesis of RP03707. It has a molecular weight of 341.14. The product is for research use only and has not been fully validated for medical applications.
- Ligand for E3 ligase
- Used for the synthesis of RP03707
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Medchemexpress LLC ML171 STANDARD 250 mg
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ML171 STANDARD 250MG
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Medchemexpress LLC CIS-EPOXYSUCCINIC AC 1G
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CIS-EPOXYSUCCINIC AC 1G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000742048 ETHYL 3-BROMOPROPANO 100G
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![Medchemexpress LLC Thiocyanic acid, 2-[5-(aminocarbonyl)-2-thienyl]-2-oxoethyl ester | 1682660-95-2 | 250mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000267057.png-250.jpg)
Medchemexpress LLC Thiocyanic acid, 2-[5-(aminocarbonyl)-2-thienyl]-2-oxoethyl ester | 1682660-95-2 | 250mg
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Arolol impurity 1 is a drug impurity
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Medchemexpress LLC N-ETHYL-D-GLUCAMINE 10G
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N-ETHYL-D-GLUCAMINE 10G
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Apexbio Technology LLC Regorafenib monohydrate 1019206-88-2 10mM (in 1mL DMSO)
Regorafenib monohydrate (CAS 1019206-88-2) is a multitargeted tyrosine kinase inhibitor that suppresses numerous intracellular and membrane receptor tyrosine kinases (RTKs) including VEGFR (types 1-3) PDGFR- FGFR-1 RET TIE2 c-KIT Raf-1 and BRAF (wild-type and V600E mutant) It inhibits angiogenic RTKs such as VEGFR-2 with IC50 values ranging from approximately 4 2 to 46 nM and oncogenic RTKs like c-KIT and RET with IC50 values around 1 5 to 28 nM Regorafenib demonstrates antiproliferative activity in vitro (mean IC50 1 M) and reduces tumor progression in xenograft animal models supporting its use in cancer research involving breast colorectal thyroid pancreatic cancers melanoma and gastrointestinal stromal tumors
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